Source: Good News Network
A brand new type of cancer drug that acts as a “Trojan horse” to get inside tumor cells has shown promise in patients with advanced, drug-resistant cancers.
Patients with six different cancer types, including those with cervical, bladder, ovarian and lung tumors, have responded positively to the new treatment.
Since these patients had already exhausted their other treatment options, the drug could be ready to extend their lifespans within the next five years.
The innovative new drug, called tisotumab vedotin (or TV for short), releases a toxic substance to kill cancer cells from within. The results have been so positive, the drug has now moved forward to phase II trials in cervical cancer and will be tested in a range of additional solid tumor cancers.
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A team at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust led a phase I/II global clinical trial of nearly 150 European patients with a variety of cancer types who had stopped responding to standard treatments.
The study was published in The Lancet Oncology and funded by Genmab and Seattle Genetics.
Researchers saw responses in 27% of patients with bladder cancer, 26.5% of those with cervical cancer, 14% for ovarian cancer, 13% with esophageal, 13% with non-small cell lung, and 7% with endometrial cancer (although not in any men with prostate cancer).
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Responses lasted an average of 5.7 months, and up to 9.
5 months in some patients. The main side effects reported from the study were nose bleeds, fatigue, nausea and eye problems – but halfway through the trial the researchers adjusted the protocol to reduce these eye-related effects.TV is made up of a toxic drug attached to the tail end of an antibody. The antibody is designed to seek out a receptor called “tissue factor” – present at high levels on the surface…
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