A new approach to reducing bulging tummy fats has shown promise in laboratory trials. The solution aims to “use a person’s own body fats to burn more energy, which is a natural process in babies.”
Combining a new way to deliver medicine, via a micro-needle patch, with drugs that are known to turn energy-storing white fat into energy-burning brown fat, this innovative approach developed by scientists from Nanyang Technological University, Singapore (NTU Singapore) reduced weight gain in mice on a high fat diet and their fat mass by more than 30% over four weeks.
The new type of skin patch contains hundreds of micro-needles, each thinner than a human hair, which are loaded with the drug Beta-3 adrenergic receptor agonist or another drug called thyroid hormone T3 triiodothyronine.
When the patch is pressed into the skin for about two minutes, these micro-needles become embedded in the skin and detach from the patch, which can then be removed.
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As the needles degrade, the drug molecules then slowly diffuse to the energy-storing white fat underneath the skin layer, turning them into energy-burning brown fats.
Brown fats are found in babies and they help to keep the baby warm by burning energy. As humans grow older, the amount of brown fats lessens and is replaced with visceral white fats.
Published in the journal Small Methods recently by NTU Professor Chen Peng and Assistant Professor Xu Chenjie, this approach could help to address the worldwide obesity problem without resorting to surgical operations or oral medication which could require large dosages and could have serious side effects.
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“With the embedded micro-needles in the skin of the mice, the surrounding fats started browning in five days, which helped to increase the energy expenditure of the mice, leading to a reduction in body fat gain,” said Xu, who focuses on research in drug delivery systems.
“The…
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