PHILADELPHIA — Flat brains growing on microscope slides may have revealed a new wrinkle in the story of how the brain folds.
Cells inside the brains contract, while cells on the outside grow and push outward, researchers at the Weizmann Institute of Science in Rehovot, Israel, discovered from working with the lab-grown brains, or organoids. This push and pull results in folds in the organoids similar to those found in full-size brains. Orly Reiner reported the results December 5 at the joint meeting of the American Society for Cell Biology and the European Molecular Biology Organization.
Reiner and her colleagues sandwiched human brain stem cells between a glass microscope slide…
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