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A single-dose antidote may help prevent fentanyl overdoses

Author: Maria Temming / Source: Science News

fentanyl
ANTIDOTE EXTENSION Longer-lasting medication to counteract synthetic opioids like fentanyl could help prevent overdoses.

Synthetic opioids outlast current antidotes. A nanoparticle-based alternative could fix that.

A newly developed single-dose opioid antidote lasts several days, a study in mice shows.

If the results can be duplicated in humans, the treatment may one day help prevent overdoses from deadly drugs like fentanyl.

Normally, a dose of the opioid antidote naloxone passes through a person’s body in about 30 minutes — far too quickly to fully counteract the effects of such synthetic opioids as fentanyl and carfentanil (SN Online: 5/1/18). These drugs, tens to thousands of times stronger than morphine, can linger in a person’s system for hours or even days (SN:…

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