Author: Aimee Cunningham / Source: Science News

Babies born dependent on opioids have smaller heads than babies not exposed to the drugs in the womb.
The finding, published online December 10 in Pediatrics, raises concerns that the drugs are impairing brain growth during development. And it highlights questions about the safest approach to managing opioid addiction during pregnancy, researchers say.
Pregnant women who use opioids — or the drugs methadone or buprenorphine, opioids taken to treat addiction — pass the drugs through the bloodstream to babies. Infants can become dependent on the drugs in the womb, and experience withdrawal symptoms after birth. The disorder, marked by excessive crying, tremors or difficulty sleeping or feeding, is called neonatal abstinence syndrome, or NAS (SN: 6/10/17, p. 16).
In the new study, researchers compared the head sizes of close to 860 babies born from 2014 to 2016, half with NAS and half from mothers who had not taken opioids while pregnant. Newborns with NAS had a head circumference nearly 1 centimeter smaller, on average, than babies not exposed to the drugs, the team found. And of the NAS babies, 30 percent had especially small heads. That was true for only 12 percent of babies without the condition.
A smaller head is a possible sign of a smaller brain. The new work suggests that for those NAS babies who later have learning and behavioral problems, a contributing factor may be the effect of opioids on brain growth and development, says neonatologist Jonathan Davis.
But it will be essential to determine “the actual impact of the smaller heads on how these children are developing,” says Davis, of Floating Hospital for Children at Tufts Medical Center…
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